EGFR anticorps (AA 1170-1174)

N° du produit ABIN362866

Cet anticorps anti-EGFR est un anticorps Lapin Polyclonal détectant EGFR dans WB. Adapté pour Humain, Souris et Rat. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour EGFR anticorps (AA 1170-1174) (ABIN362866)

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGFR est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-EGFR anticorps

Épitope: AA 1170-1174

Specificité: The antibody detects endogenous level of total EGFR protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Peptide sequence around AA 1170-1174 (P-D-Y-Q-Q) derived from Human EGFR. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Références pour anticorps anti-EGFR (ABIN362866)

Gui, Han, Zhang, Liang, Wang, Xuan, Yu, Shang: "Dimerization of ZIP promotes its transcriptional repressive function and biological activity." dans: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 886-95, (2012) (PubMed).

Yang, Zheng, Xia, Ji, Chen, Guo, Lyssiotis, Aldape, Cantley, Lu: "ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect." dans: Nature cell biology, Vol. 14, Issue 12, pp. 1295-304, (2012) (PubMed).

Détails sur EGFR

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Autre désignation: EGFR

Sujet: Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

Poids moléculaire: 175 kDa

NCBI Accession: NP_005219

UniProt: P00533

Pathways: Signalisation NF-kappaB, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins